Journal article
Identification of urinary biomarkers for age-related macular degeneration
RH Guymer, LW Tao, JK Goh, D Liew, O Ischenko, LD Robman, KZ Aung, T Cipriani, M Cain, AJ Richardson, PN Baird, R Langham
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2011
DOI: 10.1167/iovs.10-7120
Abstract
Purpose. Age-related macular degeneration (AMD) can be considered as a chronic low-grade systemic inflammatory disease. This study was undertaken to test the associations of AMD with the urinary proinflammatory cytokines transforming growth factor (TGF)-β1, macrophage chemoattractant protein (MCP)-1 and C3a-desArg, as potential noninvasive biomarkers for monitoring AMD. Methods. A cross-sectional study of 103 AMD cases, comprising early AMD (n = 51), geographic atrophy (GA; n = 19), or choroidal neovascularization (CNV; 33), and 54 unrelated controls, aged 73 ± 9 years, who attended the Royal Victorian Eye and Ear Hospital and private practice in Victoria, Australia. AMD status was determine..
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Funding Acknowledgements
Supported by the National Health and Medical Research Council of Australia through a Practitioner Fellowship to RHG and The Macular Society. CERA receives Operational Infrastructure Support from the Victorian Government.