Journal article
Ophthalmic phenotypes and the representativeness of twin data for the general population
PG Sanfilippo, SE Medland, AW Hewitt, LS Kearns, JB Ruddle, C Sun, CJ Hammond, TL Young, NG Martin, DA Mackey
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2011
DOI: 10.1167/iovs.11-7258
Abstract
PURPOSE. To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. METHODS. A series of birth, anthropometric, and 13 ocular biometric traits were selected for analysis: interpupillary distance (IPD), visual acuity (logMAR), spherical equivalent refractive error, corneal curvature, axial length, anterior chamber depth (ACD), central corneal thickness (CCT), intraocular pressure (IOP), optic disc, cup and rim areas, and measures of retinal vessel caliber; central retinal arteriolar equivalent (CRAE), and central retinal v..
View full abstractGrants
Awarded by National Eye Institute
Funding Acknowledgements
Supported by the Ophthalmic Research Institute of Australia and the Australian National Health and Medical Research Council. PGS is the recipient of an NHMRC postgraduate scholarship. SEM is supported by an NHMRC Sidney Sax Fellowship. CS is supported by an Australian NHMRC Public Health Postdoctoral Research Fellowship. CJH is funded by the UK National Institute for Health Research. DAM is a Pfizer Australia research fellow. CERA receives Operational Infrastructure Support from the Victorian Government.