Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Z Kote-Jarai; AAA Olama; GG Giles; G Severi; J Schleutker; M Weischer; D Campa; E Riboli; T Key; H Gronberg; DJ Hunter; P Kraft; MJ Thun; S Ingles; S Chanock; D Albanes; RB Hayes; DE Neal; FC Hamdy; JL Donovan; P Pharoah; F Schumacher; BE Henderson; JL Stanford; EA Ostrander; KD Sorensen; T Dörk; G Andriole; JL Dickinson; C Cybulski; J Lubinski; A Spurdle; JA Clements; S Chambers; J Aitken; RAF Gardiner; SN Thibodeau; D Schaid; EM John; C Maier; W Vogel; KA Cooney; JY Park; L Cannon-Albright; H Brenner; T Habuchi; HW Zhang; YJ Lu; R Kaneva; K Muir; S Benlloch; DA Leongamornlert; EJ Saunders; M Tymrakiewicz; N Mahmud; M Guy; LT O'Brien; RA Wilkinson; AL Hall; EJ Sawyer; T Dadaev; J Morrison; DP Dearnaley; A Horwich; RA Huddart; VS Khoo; CC Parker; N Van As; CJ Woodhouse; A Thompson; T Christmas; C Ogden; CS Cooper; A Lophatonanon; MC Southey; JL Hopper; DR English; T Wahlfors; TLJ Tammela; P Klarskov; BG Nordestgaard; MA Røder; A Tybjarg-Hansen; SE Bojesen; R Travis; F Canzian; R Kaaks; F Wiklund; M Aly; S Lindstrom; WR Diver; S Gapstur; MC Stern; R Corral; J Virtamo; A Cox; CA Haiman; L Le Marchand; L Fitzgerald; S Kolb

Journal article

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Z Kote-Jarai, AAA Olama, GG Giles, G Severi, J Schleutker, M Weischer, D Campa, E Riboli, T Key, H Gronberg, DJ Hunter, P Kraft, MJ Thun, S Ingles, S Chanock, D Albanes, RB Hayes, DE Neal, FC Hamdy, JL Donovan Show all

Nature Genetics | Published : 2011

DOI: 10.1038/ng.882

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven ..

View full abstract