Journal article

Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood

David C Muller, Graham G Giles, Julie Bassett, Howard A Morris, John T Manning, John L Hopper, Dallas R English, Gianluca Severi



BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this study was to examine whether circulating concentrations of sex hormones and SHBG measured in adulthood was associated with 2D:4D. METHODS: This analysis was based on a random sample from the Melbourne Collaborative Cohort Study. The sample consisted of of 1036 men and 620 post-menopausal women aged between 39 and 70 at the time of blood draw. Concentrations of circulating sex hormones were measured from plasma collected at baseline (1990-1994), while digit length was measured from hand photocopies taken during a recent follow-up (2003-2009). The outcome measures we..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (grants #126402, 209057, 170215, 251533, 450104), and infrastructure was provided by the Cancer Council Victoria. We would like to acknowledge the work of Juliet Anderson, Lily Laskaris, and Judith Heads who measured the vast majority of the digits, and the many members of the study team past and present. We would like to thank the men and women of Melbourne who participated in this study and continue to participate in the Melbourne Collaborative Cohort Study.