Journal article
Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
C Santosa, S Rasche, A Barakat, SA Bellingham, M Ho, J Tan, AF Hill, CL Masters, C McLean, G Evin
Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2011
Abstract
BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides associated with Alzheimer's disease (AD). Previous studies have indicated that BACE is elevated in the frontal cortex of AD patients. Golgi-localized γ-ear containing ADP ribosylation factor-binding proteins (GGA) control the cellular trafficking of BACE and may alter its levels. To investigate a link between BACE and GGA expression in AD, frontal cortex samples from AD (N = 20) and healthy, age-matched controls (HC, N = 17) were analyzed by immunoblotting. After normalization to the neuronal marker β-tubulin III, the data indicate an average two-fold increase of B..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank Ms Fairlie Hinton and the Victorian Brain Bank Network for providing the samples, and Pierre Tarquis for technical help. This work was supported in part by the National Health and Medical Research Council of Australia, by the ANZ Mason & Williams Memorial Foundation, and by the AMS Universitas 21 Indonesia program from the University of Melbourne. SAB is supported by an NHMRC Biomedical Training Fellowship. AFH is supported by an NHMRC Career Development Award. GE and MH are supported by NHMRC project grant 566520. The funding sources had no input in any aspect of the study.