The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression
Peter Chan, Andreas Moeller, Mira CP Liu, Jaclyn E Sceneay, Christina SF Wong, Nic Waddell, Katie T Huang, Alexander Dobrovic, Ewan KA Millar, Sandra A O'Toole, Catriona M McNeil, Robert L Sutherland, David D Bowtell, Stephen B Fox
Breast Cancer Research | BIOMED CENTRAL LTD | Published : 2011
Awarded by National Health and Medical Research Council
Awarded by Association for Cancer Research UK
Awarded by Cancer Institute NSW
This study was supported by the Victorian Breast Cancer Research Consortium, the National Health and Medical Research Council (grant 481378 (to SAO), grant 427601 (to RLS) and grant 535947 (SAO), the Association for Cancer Research UK (grant AICR 09-0676 (to AM)), Cancer Council Victoria (grant to DDB and AM) the Cancer Institute NSW (grant 07/CRF/1-06 (to SAO) and grant 07-CDF-1/28 (EAM), the Australian Cancer Research Foundation (ACRF), the RT Hall Trust and the Petre Foundation, Australia. We thank Professor Adrian L Harris for the kind donation of the breast tumor DNA for methylation analysis.