Journal article
The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression
P Chan, A Möller, MCP Liu, JE Sceneay, CSF Wong, N Waddell, KT Huang, A Dobrovic, EKA Millar, SA 'Toole, CM McNeil, RL Sutherland, DD Bowtell, SB Fox
Breast Cancer Research | Published : 2011
DOI: 10.1186/bcr2828
Abstract
Introduction: The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-α; however, its role in breast carcinoma is unclear. We investigated the frequency and expression pattern of SIAH2 in two independent cohorts of sporadic breast cancers.Methods: Immunohistochemical evaluation of SIAH2protein expression was conducted in normal breast tissues and in tissue microarrays comprising ductal carcinoma in situ (DCIS) and a cohort of invasive breast carcinomas. Correlation analysis was performed between SIAH2 and clinicopathological variables and intrinsic breast cancer subgroups and validated in a cohor..
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Awarded by Petre Foundation
Funding Acknowledgements
This study was supported by the Victorian Breast Cancer Research Consortium, the National Health and Medical Research Council (grant 481378 (to SAO), grant 427601 (to RLS) and grant 535947 (SAO), the Association for Cancer Research UK (grant AICR 09-0676 (to AM)), Cancer Council Victoria (grant to DDB and AM) the Cancer Institute NSW (grant 07/CRF/1-06 (to SAO) and grant 07-CDF-1/28 (EAM), the Australian Cancer Research Foundation (ACRF), the RT Hall Trust and the Petre Foundation, Australia. We thank Professor Adrian L Harris for the kind donation of the breast tumor DNA for methylation analysis.