Abdominal Obesity and Age-related Macular Degeneration
Madeleine KM Adams, Julie A Simpson, Khin Zaw Aung, Galina A Makeyeva, Graham G Giles, Dallas R English, John Hopper, Robyn H Guymer, Paul N Baird, Liubov D Robman
AMERICAN JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS INC | Published : 2011
Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (~1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio = 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relati..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was supported by VicHealth; the Cancer Council Victoria (initial cohort recruitment); and the National Health and Medical Research Council of Australia (NHMRC) (program grant 209057, capacity building grant 251533, and enabling grant 396414). The ophthalmic component was funded by the Ophthalmic Research Institute of Australia, American Health Assistance Foundation, John Reid Charitable Trust, Perpetual Trustees, and the Royal Victorian Eye and Ear Hospital. People support was provided through the NHMRC Practitioner Fellowship to R. H. G., Wagstaff Fellowship to L. D. R., and an NHMRC PhD. scholarship and Hugh Noel Puckle Scholarship to M. K. M. A. The Centre for Eye Research Australia (CERA) receives operational infrastructure support from the Victorian Government.