Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial

Abstract

Dental products containing calcium phosphate and fluoride are claimed to enhance enamel remineralization over fluoride products. Objectives: To compare remineralization of enamel subsurface lesions by dental products with added calcium phosphate in a double-blind, randomized, cross-over in situ study. Methods: Human enamel specimens with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1 g product plus 4 ml H2O) of each product was rinsed for 60 s, 4 times per day for 10 days. Six products were tested (i) placebo, (ii) 1000 ppm F, (iii) 5000 ppm F, (iv) Tooth Mousse (TM), (v) TM plus 900 ppm F (TMP) and (vi) Clinpro with 950 ppm F. Calciu..