Journal article

Brain plasticity in relapsing-remitting multiple sclerosis: Evidence from resting-state fMRI

Yaou Liu, Peipeng Liang, Yunyun Duan, Xiuqin Jia, Chunshui Yu, Min Zhang, Fei Wang, Mo Zhang, Huiqing Dong, Jing Ye, Helmut Butzkueven, Kuncheng Li

Journal of the Neurological Sciences | ELSEVIER | Published : 2011


The purpose of this study is to investigate whether spontaneous brain activity amplitude alteration occurs in RRMS by comparing appropriately processed fMRI data from subjects with RRMS and healthy controls. Resting-state fMRIs collected from thirty-five RRMS patients and thirty-five age and sex-matched normal controls were compared to investigate the ALFF difference between the two groups. The relationships between ALFF in regions with significant group differences and the EDSS (Expanded Disability Status Scale), disease duration, T2 lesion volume were further explored. Our results showed that RRMS patients showed no regions with decreased ALFF, while showed significantly increased ALFF in ..

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Awarded by National Health and Medical Research (Australia)

Awarded by China Postdoctoral Science Foundation

Awarded by National Natural Science of China

Funding Acknowledgements

Dr. Yaou Liu is supported by McDonald Fellowship from Multiple Sclerosis International Federation (MSIF). Dr. Helmut Butzkueven is supported by a National Health and Medical Research (Australia) Career Development Award (628856). Dr. Peipeng Liang is supported by China Postdoctoral Science Foundation funded project (No. 201003142). This work is supported by the State Key Program of National Natural Science of China (NO. 30930029).