Journal article
Variable impact of CD39 in experimental murine colitis
BM Künzli, PO Berberat, K Dwyer, S Deaglio, E Csizmadia, P Cowan, A D'Apice, G Moore, K Enjyoji, H Friess, SC Robson
Digestive Diseases and Sciences | SPRINGER | Published : 2011
Abstract
Background: Dysregulation of immune responses in inflammatory bowel diseases (IBD) results in intestinal inflammation and vascular injury while exacerbating systemic disease. CD39 is an ectonucleotidase, expressed by T regulatory cells and dendritic cells, that hydrolyzes extracellular nucleotides to modify those cellular immune responses implicated in IBD. Genetic polymorphisms of CD39 have been linked to Crohn's disease while gene deletion in mice exacerbates dextran sodium sulphate-induced colitis. Aim: The aim of this study was to test how global deletion of CD39 in mice impacts other models of experimental colitis. Methods: Colitis was induced in CD39-null and -wt mice, using trinitrobe..
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Awarded by National Institutes of Health
Funding Acknowledgements
Supported by the German Research Foundation (DFG, KU-1957/3-1), the Lautenschlager Stipendium der Heidelberger Stiftung Chirurgie (to BMK) and the National Institutes of Health (NIH HL63972 and HL076540; to SCR).