Changes in the solubility and phosphorylation of alpha-synuclein over the course of Parkinson's disease
Jinxia Zhou, Melissa Broe, Yue Huang, John P Anderson, Wei-Ping Gai, Elizabeth A Milward, Michelle Porritt, David Howells, Andrew J Hughes, Xiaomin Wang, Glenda M Halliday
Acta Neuropathologica | SPRINGER | Published : 2011
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by National Institute of Alcohol Abuse and Alcoholism (NIH NIAAA)
Awarded by National Basic Research Program of China
Awarded by NSFC
Human brain tissue samples were received from the Australian Brain Bank Network which is supported by the National Health and Medical Research Council of Australia (NHMRC), specifically from the Sydney Brain Bank (also supported by Neuroscience Research Australia and the University of New South Wales), from the NSW Tissue Resource Centre [also supported by the Schizophrenia Research Institute, the National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) R24AA012725, and the University of Sydney], from the South Australian Brain Bank (also supported by the Flinders Medical Centre Foundation), from the Victorian Brain Bank Network (also supported by Neurosciences Australia, the University of Melbourne, the Mental Health Research Institute of Victoria, the Alfred Hospital, and the Victorian Forensic Institute of Medicine), from the Queensland Brain Bank and from the Western Australia Brain Bank Network. This work was also supported by the NHMRC (510186) and the National Basic Research Program of China (2006CB500700), NSFC fund (30771062). Gai has a NHMRC Senior Research Fellowship 535014. Halliday has a NHMRC Senior Principal Research Fellowship 630434. We would like to thank Heather McCann for laboratory assistance and Heidi Cartwright for the preparation of the figures.