Journal article
Defining the hematopoietic stem cell niche: The chicken and the egg conundrum
S Singbrant, M Askmyr, LE Purton, CR Walkley
Journal of Cellular Biochemistry | WILEY-BLACKWELL | Published : 2011
DOI: 10.1002/jcb.23085
Abstract
Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. ..
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Funding Acknowledgements
[ "Grant sponsor: Swedish Research Council; Grant sponsor: Swedish Tegger Foundation; Grant sponsor: NHMRC; Grant sponsor: Baker Foundation; Grant sponsor: Association for International Cancer Research.", "We apologize to those whose work could not be cited due to reference limits. We thank Jack Martin for helpful discussion and comment. Research support from: Swedish Research Council (S. S. and M. A.); Swedish Tegger Foundation (S. S.); NHMRC Senior Research Fellow (L. P.); NHMRC Career Development Award (C. W.); Leukaemia Foundation Phillip Desbrow Senior Research Fellowship (C. W.); NHMRC (L. P. and C. W.), Baker Foundation (C. W.), Association for International Cancer Research (L.P.)." ]