Journal article
A dual radiologic contrast agent protocol for 18F-FDG and 18F-FLT PET/CT imaging of mice bearing abdominal tumors
N Aide, K Kinross, JM Beauregard, O Neels, T Potdevin, P Roselt, D Dorow, C Cullinane, RJ Hicks
Molecular Imaging and Biology | SPRINGER | Published : 2011
Abstract
Purpose: The aim of the study was to improve abdominal tumor detection by use of a dual radiologic contrast protocol. Procedures: eXia160® (Benitio international) was mixed with 2-deoxy-2-[18F]fluoro-d-glucose or 3′-[18F]fluoro-3′-deoxythymidine for intravenous (IV) injections. Omnipaque® 300 (GE healthcare) was used for intraperitoneal (IP) injections. Positron emission tomography/computed tomography (PET/CT) scans were acquired on a Siemens Biograph® equipped with point spread function reconstruction. The optimal concentration and injection schedule of IP contrast agent was studied in 12 mice. The impact of IP contrast media on PET quantitative accuracy was investigated by phantom studies ..
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Funding Acknowledgements
This work was supported and by a Fellowship from the Fondation de France, and by a grant from the French Ligue contre le cancer, Comite du Calvados. The authors thank Emily Hong, Jason Callahan, David Binns and Mark Scalzo for their help during animals PET acquisitions and ex vivo counting and the animal technologists and research assistants (Kerry Ardley, Rachel Walker, Susan Jackson, Jeannette Valentan, Ekaterina Bogatyreva and Laura Kirby) from the Centre for Molecular Imaging for animal care and tracer injections. Dr. Aide is indebted to Dr. Lerouge for her continuous support during this work.