A Longitudinal Study of Plasma and Urinary Cortisol in Pregnancy and Postpartum
Caroline Jung, Jui T Ho, David J Torpy, Anne Rogers, Matt Doogue, John G Lewis, Raymond J Czajko, Warrick J Inder
Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2011
CONTEXT: There is a paucity of longitudinal data on plasma and urinary cortisol levels during pregnancy using modern assays. Furthermore, conflicting data exist as to the effect of the low-dose oral contraceptive pill (OCP) on cortisol. DESIGN, SUBJECTS, AND MEASUREMENTS: We conducted a prospective longitudinal study on morning plasma cortisol (total and free), corticosteroid-binding globulin (CBG), and 24-h urinary free cortisol (UFC) levels in 20 pregnant women during the first, second, and third trimesters and 2-3 months postpartum compared with 12 subjects on low-dose OCP and 15 nonpregnant subjects not taking the OCP (control group). RESULTS: A progressive rise in total plasma cortisol,..View full abstract
C.J. has received a research grant from St Vincent's Hospital, Victoria, and an Australian Postgraduate Award Scholarship from the University of Melbourne, Australia.