Journal article
Antioxidant network expression abrogates oxidative posttranslational modifications in mice
R Mital, W Zhang, M Cai, ZM Huttinger, LA Goodman, DG Wheeler, MT Ziolo, KM Dwyer, AJF d'Apice, JL Zweier, G He, PJ Cowan, RJ Gumina
American Journal of Physiology Heart and Circulatory Physiology | Published : 2011
Abstract
Antioxidant enzymatic pathways form a critical network that detoxifies ROS in response to myocardial stress or injury. Genetic alteration of the expression levels of individual enzymes has yielded mixed results with regard to attenuating in vivo myocardial ischemia-reperfusion injury, an extreme oxidative stress. We hypothesized that overexpression of an antioxidant network (AON) composed of SOD1, SOD3, and glutathione peroxidase (GSHPx)-1 would reduce myocardial ischemia-reperfusion injury by limiting ROS-mediated lipid peroxidation and oxidative posttranslational modification (OPTM) of proteins. Both ex vivo and in vivo myocardial ischemia models were used to evaluate the effect of AON exp..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported by National Heart, Lung, and Blood Institute Grant K08-HL-094703 and 10UFEL4180090 (to R. J. (lumina), an American Heart Association-Groat Rivers Affiliate Student Undergraduate Research Fellowship (to Z. M. Huttinger and L. A. Goodman), an A Omega A Carolyn L. Kuckein Student Research Fellowship (to R. Mital), and the Davis Heart and Lung Research Institute and Ross Academic Advisory Committee (to R. J. Gumina).