Journal article
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
VL Villemagne, KE Pike, G Chételat, KA Ellis, RS Mulligan, P Bourgeat, U Ackermann, G Jones, C Szoeke, O Salvado, R Martins, G O'Keefe, CA Mathis, WE Klunk, D Ames, CL Masters, CC Rowe
Annals of Neurology | Published : 2011
DOI: 10.1002/ana.22248
Abstract
Objective: Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression. Methods Clinical follow-up was obtained 20 ± 3 months after [11C]Pittsburgh compound B (PiB)-positron emission tomography in 206 subjects: 35 with dementia of the Alzheimer type (DAT), 65 with mild cognitive impairment (MCI), and 106 age-matched healthy controls (HCs). A second PiB scan was obtained at follow-up in 185 subjects and a third scan after 3 years in 57. Results At baseline, 97% of DAT, 69% of MCI, and 31% of HC subjects showed high PiB retention. At 20-month follow-up, small but significant increases in PiB standardized uptake value ratios were observed in the DAT a..
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Awarded by National Institute on Aging
Funding Acknowledgements
The study was partially supported by the Commonwealth Scientific Industrial Research Organization Preventative Health Flagship Program through the Australian Imaging, Biomarkers, and Lifestyle flagship study of aging, the Austin Hospital Medical Research Foundation, Neurosciences Victoria, and the University of Melbourne. The funding sources had no input into the design of this study, the analysis of data, or writing of the manuscript. GE Healthcare holds a license agreement with the University of Pittsburgh based on the technology described in this article. W.E.K. and C.A.M. have received consultancy fees and royalties and have a grant pending from GE Healthcare. W.E.K. and C.A.M. are coinventors of PiB and, as such, have a financial interest in this license agreement. GE Healthcare provided no grant support for this study and had no role in the design or interpretation of results or preparation of the manuscript. All other authors have no conflicts of interest with this work, had full access to all of the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis.