Journal article

Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study

Andreas Bechdolf, Stephen J Wood, Barnaby Nelson, Dennis Velakoulis, Murat Yuecel, Tsutomu Takahashi, Alison R Yung, Michael Berk, Michael T Wong, Christos Pantelis, Patrick D McGorry



There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328 days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12 months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala..

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Awarded by National Health & Medical Research Council (NHMRC)

Awarded by German Research Foundation

Awarded by Japanese Society for the Promotion of Science

Funding Acknowledgements

This study was supported by project grants from the National Health & Medical Research Council (NHMRC; grant IDs: 145627, 145737, 970598, 981112, 970391), NHMRC Program Grant (ID: 350241), and the Colonial Foundation. Dr Bechdolf was supported by a grant from the German Research Foundation (Be 3697/1-1). Prof. Wood was supported by a Clinical Career Development Award from the NHMRC (ID: 359223). Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science.