Degradation of liposomal subcompartments in PEGylated capsosomes

Abstract

Capsosomes, polymer hydrogel capsules containing intact liposomal subcompartments, represent a promising platform toward the assembly of cell-like systems. Compartmentalized assembly plays a key role in the creation of therapeutic artificial cells, which focuses on enzymatic activities to degrade waste products or to support the synthesis of biomolecules. A fundamental aspect that governs the success of continuous enzymatic reactions in capsosomes is the long-term stability of the liposomal subunits within the polymer hydrogel capsules at physiological conditions, as they are subject to degradation in the presence of lipases. In this study, the outer membrane of the capsosomes was PEGylated ..