Journal article
Exploring the tolerability of spatiotemporally complex electrical stimulation paradigms
TS Nelson, CL Suhr, A Lai, AJ Halliday, DR Freestone, KJ McLean, AN Burkitt, MJ Cook
Epilepsy Research | ELSEVIER | Published : 2011
Abstract
A modified cortical stimulation model was used to investigate the effects of varying the synchronicity and periodicity of electrical stimuli delivered to multiple pairs of electrodes on seizure initiation. In this model, electrical stimulation of the motor cortex of rats, along four pairs of a microwire electrode array, results in an observable seizure with quantifiable electrographic duration and behavioural severity. Periodic stimuli had a constant inter-stimulus intervals across the two-second stimulus duration, whilst synchronous stimuli consisted of singular biphasic, bipolar pulses delivered to the four pairs of electrodes at precisely the same time for the entire two second stimulatio..
View full abstractGrants
Funding Acknowledgements
The authors wish to acknowledge the support of the State Government of Victoria through the Science and Technology Innovation Initiative, as well as the assistance of Associate Professor Antonio Paolini in the initial establishment of the laboratory facilities. The Bionic Ear Institute acknowledges the support it receives from the Helen Macpherson Smith Trust and the State Government of Victoria through the Operational Infrastructure Support Program.