Heartworm Genomics: Unprecedented Opportunities for Fundamental Molecular Insights and New Intervention Strategies
Robin B Gasser, Cinzia Cantacessi
TOPICS IN COMPANION ANIMAL MEDICINE | W B SAUNDERS CO-ELSEVIER INC | Published : 2011
Vector-borne diseases, including canine heartworm disease (CHWD), are of major socioeconomic and canine health importance worldwide. Although many studies have provided insights into CHWD, to date there has been limited study of fundamental molecular aspects of Dirofilaria immitis itself, its relationship with the canine host, its vectors, as well as the potential of drug resistance to emerge, using advanced -omic technologies. This article takes a prospective view of the benefits that advanced -omics technologies will have toward understanding D. immitis and CHWD. Tackling key biological questions using these technologies will provide a "systems biology" context and could lead to radically ..View full abstract
Current research in the Gasser Lab is funded mainly through the Australian Research Council (ARC), the National Health & Medical Research Council (NHMRC), and Melbourne Water Corporation.