The Minimal Active Structure of Human Relaxin-2
Mohammed Akhter Hossain, K Johan Rosengren, Chrishan S Samuel, Fazel Shabanpoor, Linda J Chan, Ross AD Bathgate, John D Wade
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2011
H2 relaxin is a peptide hormone associated with a number of therapeutically relevant physiological effects, including regulation of collagen metabolism and multiple vascular control pathways. It is currently in phase III clinical trials for the treatment of acute heart failure due to its ability to induce vasodilation and influence renal function. It comprises 53 amino acids and is characterized by two separate polypeptide chains (A-B) that are cross-linked by three disulfide bonds. This size and complex structure represents a considerable challenge for the chemical synthesis of H2 relaxin, a major limiting factor for the exploration of modifications and derivatizations of this peptide, to o..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC, Australia)
This work was supported by National Health and Medical Research Council (NHMRC, Australia) Project Grants 350284 and 508995 (to J. D. W. and R. A. D. B.). Studies at the FNI were supported by the Victorian Government's Operational Infrastructure support program.