Journal article

Compliance in a school-based caries clinical trial of a sugar-free chewing gum

Denise Louise Bailey, Adele Christine Campain, Claudine Elizabeth Tsao, Geoffrey Grant Adams, Wendy Joy Thomson, Michael Vivian Morgan

CONTEMPORARY CLINICAL TRIALS | ELSEVIER SCIENCE INC | Published : 2011

Abstract

UNLABELLED: There is currently little reliable and quantifiable compliance data reported for preventive trials of oral disease. During a two-year, school-based caries clinical trial of sugar-free chewing gum, strategies to promote compliance with a gum-chewing protocol were implemented and outcomes measured. METHODS: Over a 28-month period 2720 subjects, aged 11½-13½ at baseline, were recruited from 29 secondary colleges in Melbourne, Australia. Subjects were required to chew gum (test or control) for 10 min 3× daily, including once during a supervised school chewing session. The main compliance promotion strategies were regular school visits, regular provision of information and performance..

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Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

The authors would like to acknowledge the significant contributions to the design, execution and analysis of this study made by staff members from the Clinical Trial Group at the Melbourne Dental School, The University of Melbourne; Dr D. Tancredi, Dr D. Ming and staff members of Cadbury Schweppes Science and Technology; and the trial monitor, Mr. M. Boschenok. This study would not have been possible without the cooperation of the Victorian Department of Education and the principals, teachers, parents and students at the participating schools. Support for this study was provided by Cadbury Schweppes Science and Technology and the Australian National Health and Medical Research Council Development Grant no 991501. Author Adele Campain passed away during the preparation of this manuscript.