Journal article
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
JR Lingappa, S Petrovski, E Kahle, J Fellay, K Shianna, MJ McElrath, KK Thomas, JM Baeten, C Celum, A Wald, G de Bruyn, JI Mullins, E Nakku-Joloba, C Farquhar, M Essex, D Donnell, J Kiarie, B Haynes, D Goldstein
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use. Methods: We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfect..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
Funding for this work was through the Bill and Melinda Gates Foundation grant #26469 and NIH/NIAID grants AI27757, AI073115 and Center for HIV-1/AIDS Vaccine Immunology grant AI067854. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.