Journal article

Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure

Jairam R Lingappa, Slave Petrovski, Erin Kahle, Jacques Fellay, Kevin Shianna, M Juliana McElrath, Katherine K Thomas, Jared M Baeten, Connie Celum, Anna Wald, Guy de Bruyn, James I Mullins, Edith Nakku-Joloba, Carey Farquhar, Max Essex, Deborah Donnell, James Kiarie, Bart Haynes, David Goldstein

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011

Abstract

BACKGROUND: Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 serodiscordant heterosexual couples. To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use. METHODS: We matched couples without HIV-1 seroconversion to those with seroconversion by quantified HIV-1 exposure risk. Logistic regression of single nucleotide polymorphisms (SNPs) for 798 samples from 496 HIV-1 infected and 302 HIV-1 exposed, uninfect..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Bill and Melinda Gates Foundation


Awarded by NIH/NIAID


Awarded by Center for HIV-1/AIDS Vaccine Immunology


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

Funding for this work was through the Bill and Melinda Gates Foundation grant #26469 and NIH/NIAID grants AI27757, AI073115 and Center for HIV-1/AIDS Vaccine Immunology grant AI067854. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.