Journal article
Variations in apolipoprotein e frequency with age in a pooled analysis of a large group of older people
GJ McKay, G Silvestri, U Chakravarthy, S Dasari, LG Fritsche, BH Weber, CN Keilhauer, ML Klein, PJ Francis, CC Klaver, JR Vingerling, L Ho, PTDV De Jong, M Dean, J Sawitzke, PN Baird, RH Guymer, D Stambolian, A Orlin, JM Seddon Show all
American Journal of Epidemiology | Published : 2011
DOI: 10.1093/aje/kwr015
Abstract
Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms ε2, ε3, and ε4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD. In an analysis stratified by study center, gender, and smoking status, there was a decreasing frequency of the APOE ε4 isoform wit..
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Awarded by National Eye Institute
Funding Acknowledgements
Funding was provided by the Guide Dogs for the Blind Association (Reading, United Kingdom) (grants 2008-5a [Giuliana Silvestri] and OR2006-02d [John R. Yates]); the United Kingdom Medical Research Council (grant G0000067 [John R. Yates]); the Estonian Ministry of Science and Education (grant SF0940026s07 [Mati Rahu]); the Research and Development Office of Northern Ireland Health Personal Social Services (grant RRG 4.5 [Giuliana Silvestri]); EVI-GENORET, an integrated project funded through the European Union Research Project (grant FP6 [Usha Chakravarthy]); the Deutsche Forschungsgemeinschaft (grants WE1259/18-1 and WE1259/19-1 [Bernhard H. Weber]); the Alcon Research Institute and the Ruth and Milton Steinbach Foundation (New York, New York) (Bernhard H. Weber); a Russo Grant from Tufts University School of Medicine (Johanna M. Seddon); the Macular Degeneration Research Fund-Tufts Medical Center (Johanna M. Seddon); the Massachusetts Lions Eye Research Fund (Johanna M. Seddon); Research to Prevent Blindness USA (Michael L. Klein, Peter J. Francis); the Foundation Fighting Blindness (Peter J. Francis); financial support from the United Kingdom Department of Health through an award made by the National Institute for Health Research to Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology for a Specialist Biomedical Research Centre for Ophthalmology (John R. Yates); the JACOM Foundation (Paul N. Baird); and a National Health and Medical Research Council (Canberra, Australia) Practitioner Award (Robyn H. Guymer). The Centre for Eye Research Australia receives operational infrastructure support from the Victorian government (Paul N. Baird, Robyn H. Guymer), the Macular Disease Society (Gareth J. McKay, Andrew J. Lotery), the T.F.C. Frost Charity (Andrew J. Lotery), and the British Council for the Prevention of Blindness (Andrew J. Lotery). Genetic analysis in the European Eye Study was supported by an MRC Biomarker Award (grant G0601354 [Aroon D. Hingorani, Astrid E. Fletcher]).