Journal article
Dietary monounsaturated fat in early life regulates IGFBP2: Implications for fat mass accretion and insulin sensitivity
MA Sabin, SW Yau, VC Russo, IJ Clarke, FR Dunshea, J Chau, M Cox, GA Werther
Obesity | WILEY | Published : 2011
DOI: 10.1038/oby.2011.55
Abstract
The aim of this study was to investigate effects of dietary supplementation with fat or sugar on body composition (BC) and insulin sensitivity (IS) in maturing pigs. Fifty newborn pigs randomized to a control diet or 18% saturated fat (SF), 18% monounsaturated fat (MUF), 18% mixed fat (MF), or 50% sucrose (SUC), from 1 to 16 weeks of age. Outcomes included weight gain, BC (dual energy X-ray absorptiometry, DXA), IS (fasting insulin and hyperinsulinaemic- euglycaemic clamps), fasting Non-Esterified Fatty Acid (NEFA) concentrations, and mRNA expression of genes involved in lipogenesis and IS in skeletal muscle (SM), subcutaneous (SAT), and visceral adipose tissue (VAT). In vitro studies examin..
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Funding Acknowledgements
Funding for this study was from the Murdoch Childrens Research Institute. We are grateful to staff at the Department of Primary Industries (Melbourne, Australia) for their assistance with the porcine aspects of this study, as well as Ms Alexandra Rao and colleagues at Monash University (Melbourne, Australia) for help with biochemical analysis of the porcine serum samples.