Journal article
Apoe genotype and Cardio-Respiratory fitness interact to determine adiposity in 8-Year-Old children from the Tasmanian infant health survey
JA Ellis, AL Ponsonby, A Pezic, E Williamson, JA Cochrane, JL Dickinson, T Dwyer
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
APOE plays a well established role in lipid metabolism. Animal model evidence suggests APOE may also be associated with adiposity, but this has not been thoroughly investigated in humans. We measured adiposity (BMI, truncal fat mass, waist circumference), physical activity (PA), cardiorespiratory fitness and APOE genotype (E2, E3, E4) in 292 8-year-old children from the Tasmanian Infant Health Survey (TIHS), an Australian population-based prospective birth cohort. Our aims were to examine the association of APOE with child adiposity, and to examine the interplay between this association and other measured factors. We found that APOE was associated with child lipid profiles. APOE was also ass..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
The Tasmanian Infant Health Survey was funded by the Australian National Health and Medical Research Council (NHMRC), United States of America National Institutes of Health (grant 001 HD28979-01A1), Tasmanian State Government, Australian Rotary Health Research Fund, Sudden Infant Death Syndrome Research Foundation, National Sudden Infant Death Syndrome Council of Australia, Community Organizations' support program of the Department of Human Services and Health, Zonta International, Wyeth Pharmaceuticals and the Tasmanian Sanatoria After-Care Association. JE was supported by an Australian National Health and Medical Research Council Capacity Building Grant in Population Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.