Journal article

Birthweight and mortality in adulthood: a systematic review and meta-analysis

Kari R Risnes, Lars J Vatten, Jennifer L Baker, Karen Jameson, Ulla Sovio, Eero Kajantie, Merete Osler, Ruth Morley, Markus Jokela, Rebecca C Painter, Valter Sundh, Geir W Jacobsen, Johan G Eriksson, Thorkild IA Sorensen, Michael B Bracken

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2011


BACKGROUND: Small birth size may be associated with increased risk of cardiovascular diseases (CVD), whereas large birth size may predict increased risk of obesity and some cancers. The net effect of birth size on long-term mortality has only been assessed in individual studies, with conflicting results. METHODS: The Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines for conducting and reporting meta-analysis of observational studies were followed. We retrieved 22 studies that assessed the association between birthweight and adult mortality from all causes, CVD or cancer. The studies were systematically reviewed and those reporting hazard ratios (HRs) and 95% confidenc..

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