Kallikrein-Kinin System: A Surgical Perspective in Post-Aprotinin Era
Pankaj Saxena, Philip Thompson, Yves d'Udekem, Igor E Konstantinov
JOURNAL OF SURGICAL RESEARCH | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2011
Kallikrein-kinin system (KKS) plays an important role in inflammation, ischemia-reperfusion (IR) injury, and development of neoplasia. There is evidence to suggest that KKS plays an important role in organ protection during preconditioning. Aprotinin is a nonspecific serine protease inhibitor, which has been extensively used in cardiac surgery for the control of post operative bleeding. The anti-inflammatory effects of aproprotin are due to its inhibitory effect on the kallikrein-kinin system (KKS). We herein review KKS and its role as applied to the practice of surgery.
Awarded by National Health and Medical Research Council of Australia (NHMRC)
This study was supported by the National Health and Medical Research Council of Australia (NHMRC), project grant 557507.