Journal article

Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors

Markus Juonala, Costan G Magnussen, Gerald S Berenson, Alison Venn, Trudy L Burns, Matthew A Sabin, Sathanur R Srinivasan, Stephen R Daniels, Patricia H Davis, Wei Chen, Cong Sun, Michael Cheung, Jorma SA Viikari, Terence Dwyer, Olli T Raitakari

New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2011

Abstract

BACKGROUND: Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS: We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS: Data were available for 6328 subjects. Subjects with c..

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Grants

Awarded by Academy of Finland


Awarded by National Health and Medical Research Council


Awarded by National Institute on Aging


Awarded by National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH)


Awarded by National Heart, Lung, and Blood Institute


Awarded by NIH


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

These analyses were supported by funding from the individual studies. The Cardiovascular Risk in Young Finns Study was supported by grants from the Academy of Finland (121584, 126925, 124282, 129378), the Social Insurance Institution of Finland, the Turku University Foundation, Special Federal Grants for University Hospitals, the Juho Vainio Foundation, Paavo Nurmi Foundation, the Finnish Foundation of Cardiovascular Research, Orion-Farmos Research Foundation, and the Finnish Cultural Foundation. The Childhood Determinants of Adult Health study was supported at baseline by the Commonwealth Departments of Sport, Recreation and Tourism, and Health; the National Heart Foundation; and the Commonwealth Schools Commission and at follow-up by the National Health and Medical Research Council, the Heart Foundation, the Tasmanian Community Fund, and Veolia Environmental Services; authors from the Murdoch Children's Research Institute are supported by the Victorian Government Operational Infrastructure Support Program; Dr. Sabin is supported through a National Health and Medical Research Council Health Professional Training Fellowship (APP1012201). The Bogalusa Heart Study was supported by grants from the National Institute on Aging (AG-16592) and the National Heart, Lung, and Blood Institute (HL-38844) of the National Institutes of Health (NIH) and from the American Heart Association. The Muscatine Study was supported by grants from the National Heart, Lung, and Blood Institute (HL-14230 and HL-54730), and the General Clinical Research Centers Program (RR-00059) of the NIH.Dr. Sabin reports receiving lecture fees from Pfizer; Dr. Daniels, receiving consulting fees from Merck; and Dr. Viikari, receiving lecture fees from Merck, AstraZeneca, and Pfizer. No other potential conflict of interest relevant to this article was reported.