Journal article

The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study

Chloe YY Cheung, Annette WK Tso, Bernard MY Cheung, Aimin Xu, Carol HY Fong, KL Ong, Lawrence SC Law, Nelson MS Wat, Edward D Janus, Pak C Sham, Karen SL Lam

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011


CONTEXT: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. OBJECTIVE: This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. METHODS/PRINCIPAL FINDINGS: We performed a long-term prospective study on 1912 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS). The KCNJ11 E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P(ag..

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