The KCNJ11 E23K Polymorphism and Progression of Glycaemia in Southern Chinese: A Long-Term Prospective Study
Chloe YY Cheung, Annette WK Tso, Bernard MY Cheung, Aimin Xu, Carol HY Fong, KL Ong, Lawrence SC Law, Nelson MS Wat, Edward D Janus, Pak C Sham, Karen SL Lam
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011
CONTEXT: The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies. OBJECTIVE: This study aimed to evaluate whether the E23K variant could predict glycaemic progression in a Southern Chinese population. METHODS/PRINCIPAL FINDINGS: We performed a long-term prospective study on 1912 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS). The KCNJ11 E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P(ag..View full abstract
This study was financially supported by the CRCG seeding fund for basic research from the University of Hong Kong to Karen SL Lam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.