Functionalized Nanowire-Based Antigen Detection Using Frequency-Based Signals
Cong Nguyen Thanh, Wanzhi Z Qiu, Efstratios Skafidas
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2012
As part of clinical diagnosis, a clinician is required to detect disease causing antigens, bacteria, or viruses in serum, saliva, or other biological samples. Usually, this requires the sample to be sent to a pathology laboratory for analysis. Silicon nanowires can be made into sensitive molecular sensors. When being functionalized with antibodies, they are capable of detecting femto molar concentrations of antigens in real time. Biological molecules at a pH different from their isoelectric point exhibit a net charge. When an antigen attaches to the antibody on the nanowire, the net charged on the antigen displaces free carriers in the nanowire changing its conductance. To date, detection me..View full abstract
This work was carried out at the University of Melbourne, Parkville, Australia. This work was supported by National ICT Australia. Asterisk indicates corresponding author.