Trends in the epidemiology of multiple sclerosis in Greater Hobart, Tasmania: 1951 to 2009
Steve Simpson, Fotini Pittas, Ingrid van der Mei, Leigh Blizzard, Anne-Louise Ponsonby, Bruce Taylor
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | BMJ PUBLISHING GROUP | Published : 2011
BACKGROUND: Hobart, Tasmania, has been the site of two major studies of multiple sclerosis (MS) frequency, in 1951-1961 and 1971-1981. Since then, there have been no studies of MS frequency in Hobart. METHODS: Using a prevalent cohort of 226 cases in 2001 and 265 in 2009, the authors undertook a two-stage survey of MS frequency in Hobart. Combined with the published data from the two preceding studies, the authors conducted a time-trend analysis of MS epidemiology over 1951-2009. RESULTS: The age-standardised prevalence in 2001 was 96.6/100 000, and 99.6/100 000 in 2009, a significant increase from the 1961 prevalence of 32.5/100 000 (p<0.001). Female prevalence increased over each time poin..View full abstract
Awarded by National Health and Medical Research Council of Australia
The Multiple Sclerosis Longitudinal Study was funded by a grant from the National Health and Medical Research Council of Australia (Project 333105). The Multiple Sclerosis Prevalence and Genetics study was funded by a principle research fellowship from the Menzies Research Institute.