Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
Boris Novakovic, Ryan K Yuen, Lavinia Gordon, Maria S Penaherrera, Andrew Sharkey, Ashley Moffett, Jeffrey M Craig, Wendy P Robinson, Richard Saffery
BMC Genomics | BMC | Published : 2011
BACKGROUND: The human placenta facilitates the exchange of nutrients, gas and waste between the fetal and maternal circulations. It also protects the fetus from the maternal immune response. Due to its role at the feto-maternal interface, the placenta is subject to many environmental exposures that can potentially alter its epigenetic profile. Previous studies have reported gene expression differences in placenta over gestation, as well as inter-individual variation in expression of some genes. However, the factors contributing to this variation in gene expression remain poorly understood. RESULTS: In this study, we performed a genome-wide DNA methylation analysis of gene promoters in placen..View full abstract
BN is supported by an NHMRC (Australia) Dora Lush Biomedial Postgraduate Scholarship. RKCY is supported by a graduate student scholarship from the Child & Family Research Institute. The Vancouver data was funded by a Canadian Institutes for Health Research Grant (to WPR). The Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.