Journal article
Microarray-based comparative genomic hybridization of cancer targets reveals novel, recurrent genetic aberrations in the myelodysplastic syndromes
KA Kolquist, RA Schultz, A Furrow, TC Brown, JY Han, LJ Campbell, M Wall, ML Slovak, LG Shaffer, BC Ballif
Cancer Genetics | ELSEVIER SCIENCE INC | Published : 2011
Abstract
The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders characterized by ineffective hematopoiesis, cytopenias, and a risk of transformation to acute myeloid leukemia (AML). However, only approximately 50% of primary MDS patients show clonal cytogenetic aberrations. To determine whether high-resolution microarray analysis would reveal new or additional aberrations, we analyzed 35 samples derived from patients with a diagnosis or suspicion of MDS and abnormal karyotypes. We used a whole-genome oligonucleotide microarray with targeted coverage of approximately 1900 genes associated with hematologic and other cancers. Clinically relevant copy number aberrations (CNAs) ..
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Awarded by Korea Science and Engineering Foundation
Funding Acknowledgements
The authors thank Erin Dodge (Signature Genomic Laboratories) for her critical editing of this manuscript. Funding for this research was provided by Signature Genomic Laboratories, Perkin Elmer. Jin-Yeong Han is supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MEST; R13-2002-044-05002-0).