Comparison of risk calculators from the Prostate Cancer Prevention Trial and the European Randomized Study of Screening for Prostate Cancer in a contemporary Canadian cohort

Abstract

Study Type - Prognosis (inception cohort) Level of Evidence 1b OBJECTIVE • To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS • At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC covariables were prospectively catalogued before prostate biopsy for suspicion of prostate cancer (PCa). • Receiver-operating characteristic (ROC) curves were generated for each calculator and prostate-specific antigen (PSA). • Comparisons by area under the curve (AUC) and calibration plots were performed. • Predi..