Protein translation in Plasmodium parasites
Katherine E Jackson, Saman Habib, Magali Frugier, Rob Hoen, Sameena Khan, James S Pham, Lluis Ribas de Pouplana, Miriam Royo, Manuel AS Santos, Amit Sharma, Stuart A Ralph
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2011
The protein translation machinery of the parasite Plasmodium is the target of important anti-malarial drugs, and encompasses many promising targets for future drugs. Plasmodium parasites have three subcellular compartments that house genomes; the nucleus, mitochondrion and apicoplast, and each requires its own compartmentalized transcription and translation apparatus for survival. Despite the availability of the complete genome sequence that should reveal the requisite elements for all three compartments, our understanding of the translation machineries is patchy. We review what is known about cytosolic and organellar translation in Plasmodium and discuss the molecules that have been identif..View full abstract
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Awarded by European Union
Awarded by Australian Research Council
The authors are funded by an European Union FP7 Collaborative Project Grant HEALTH-F3-2009-223024 - Mephitis. S.A.R. is funded by Australian Research Council Future fellowship FT0990350. The authors acknowledge and apologize to the authors of many important studies in this field whose findings had to be omitted or referred to only via review papers owing to space constraints.