AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, RD Hannan, RB Pearson
Oncogene | NATURE PUBLISHING GROUP | Published : 2012
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
We acknowledge the Victorian Centre for Functional Genomics for the use of equipment and advice. This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia to RDH (NHMRC Nos. 166908 and 251688) and to RBP (NHMRC Nos. 509087 and 400116) and from Cancer Council Victoria to RBP. RDH and RBP are NHMRC Senior Research Fellows. We thank Professor Stephen Jane and Loretta Cerruti for assistance with retrovirus production.