Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling
Karen Doggett, Felix A Grusche, Helena E Richardson, Anthony M Brumby
BMC Developmental Biology | BMC | Published : 2011
Awarded by Australian National Health and Medical Research Council (NHMRC)
We thank Linda Parsons, Kieran Harvey and Patrick Humbert for helpful discussions, Greg Leong for technical help with the initial experiments looking at DIAP1 levels in scrib mutants, Barry Dickson for supplying the scrib<SUP>RNAi</SUP> transgenic flies, and D. Bilder, S. Campuzano, K. Harvey, B. Hay, J. Jiang, J. Knoblich, H. McNeill, J. Treisman, the Bloomington Stock Centre, the Vienna Drosophila RNAi Centre (VDRC), the National Institute of Genetics (NIG) Fly Stock Centre and the Developmental Studies Hybridoma Bank for contributing fly stocks and/or reagents. This work was supported by grants from the Australian National Health and Medical Research Council (NHMRC) to AMB (NHMRC Grant#350396 and Grant#509051) and HER (NHMRC Senior research Fellowship B and NHMRC Grants). FG was the recipient of a Melbourne International Research scholarship and Melbourne International Fee Remission Scholarship from the University of Melbourne. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.