Taking HSCs Down a Notch in Leukemia
Carl R Walkley, David J Izon, Louise E Purton
CELL STEM CELL | CELL PRESS | Published : 2011
The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et al. (2011) demonstrate a tumor-suppressor function for the Notch pathway in myeloid malignancy.