Journal article
The influence of bacille Calmette-Guérin vaccine strain on the immune response against tuberculosis: A randomized trial
N Ritz, B Dutta, S Donath, D Casalaz, TG Connell, M Tebruegge, R Robins-Browne, WA Hanekom, WJ Britton, N Curtis
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2012
Abstract
Approximately 100 million doses of bacille Calmette-Guérin (BCG) vaccine are given each year to protect against tuberculosis (TB). More than 20 genetically distinct BCG vaccine strains are in use worldwide. Previous studies suggest that BCG vaccine strain influences the immune response and protection against TB. Current data on which BCG vaccine strain induces the optimal immune response in humans are insufficient. Objectives: To compare the immuneresponse to three different BCG vaccine strains given to infants at birth. Methods: Newborn infants in a tertiary women's hospital were immunized at birth with one of three BCG vaccine strains. A stratified randomization according to the mother's r..
View full abstractGrants
Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
Supported by Fellowship awards from the European Society for Pediatric Infectious Diseases and scholarships from The University of Melbourne (N.R. and M. T.), by a project grant from the Australian National Health and Medical Research Council (NHMRC grant no. 546,486), and by grants from the John Burge Trust, the Myer Foundation, the Aranday Foundation, the Nossal Institute for Global Health, and the Murdoch Children's Research Institute.