Journal article
Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies
GJ Mckay, CC Patterson, U Chakravarthy, S Dasari, CC Klaver, JR Vingerling, L Ho, PTVM de Jong, AE Fletcher, IS Young, JH Seland, M Rahu, G Soubrane, L Tomazzoli, F Topouzis, J Vioque, AD Hingorani, R Sofat, M Dean, J Sawitzke Show all
Human Mutation | Published : 2011
DOI: 10.1002/humu.21577
Abstract
Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n = 21,160) demonstrating associations between late AMD and APOε4 (odds ratio [OR] = 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P = 4.41×10 -11) and APOε2 (OR = 1.83 for homozygote carriers; CI: 1.04-3.23; P = 0.04), following adjustment for age group and sex within each study and smokin..
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Awarded by UK Research and Innovation
Funding Acknowledgements
Contract grant sponsors: The Guide Dogs for the Blind Association UK (2008-5a (to G. S.) and OR2006-02d (to A. T. M. and J.R.W.Y.)); Medical Research Council (G0000067 (to J.R.W.Y. and A. T. M.)); Research and Development Office, Northern Ireland Health Personal Social Services (RRG 4.5 - GS); EVI-GENORET (FP6 - UC); The Deutsche Forschungsgemeinschaft (WE1259/18-1 and WE1259/19-1 (to B. H. F. W.)); The Alcon Research Institute and the Ruth and Milton Steinbach Foundation New York (to B. H. F. W.); Russo Grant (Tufts University School of Medicine; to J.M.S.); Macular Degeneration Research Fund (Tufts Medical Center; to J.M.S.); Massachusetts Lions Eye Research Fund (to J.M.S.); Research to Prevent Blindness USA (to M. L. K. and P.J.F.); Foundation Fighting Blindness (to P.J.F.); Department of Health (via National Institute for Health Research; (to J.R.W.Y. and A. T. M.); The National Health & Medical Research Council of Australia Centre for Clinical Research Excellence (#529923 (to R. H. G.)); Victorian Government (to P.N.B. and R. H. G.); Macular Disease Society (to G. M. K. and A.J.L.); T.F.C. Frost Charity (to A.J.L.); British Council for the Prevention of Blindness (to A.J.L.); MRC Biomarker Award (G0601354 (to A. H. and A. F.)); Estonian Ministry of Education and Science (to M. R.).