Journal article
The role of toll-like receptor variants in acute anterior uveitis
DS Pratap, LL Lim, JJ Wang, DA Mackey, LS Kearns, RJ Stawell, KP Burdon, P Mitchell, JE Craig, AJ Hall, AW Hewitt
Molecular Vision | MOLECULAR VISION | Published : 2011
Abstract
Purpose: Acute anterior uveitis (AAU) is the most common form of uveitis; however, while it is presumed to have an immunological basis, the precise underlying etiology remains elusive. Toll-like receptors (TLRs) have a key role in linking innate and adaptive immunity, thereby forming a molecular bridge between microbial triggers and the development of AAU. The purpose of this study was to investigate the role of TLR2 and TLR4 gene polymorphisms in the pathogenesis of AAU. Methods: The study comprised 225 confirmed cases of idiopathic or human leukocyte antigen (HLA) B27 (subtypes B*2701-2759; HLA-B27)-related AAU and 2,534 population-based controls from the Blue Mountains Eye Study. All part..
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Awarded by Wellcome Trust
Funding Acknowledgements
The authors gratefully acknowledge the assistance of the Western Australian DNA Bank (NHMRC Enabling Facility) with DNA samples for this study. CERA receives operational infrastructure support from the Victorian government. The Blue Mountains Eye Study (BMES) was supported by the Australian National Health & Medical Research Council, Canberra Australia (Grant No 974159, 211069, 302068, and Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases, CCRE in TCR-Eye). The BMES GWAS was supported by the Australian National Health & Medical Research Council, Canberra Australia (Grant No 512423, 475604, 529912). In addition, funding by the Wellcome Trust, UK as part of Wellcome Trust Case Control Consortium 2 (A. Viswanathan, P. McGuffin, P. Mitchell, F. Topouzis, and P. Foster) has supported the genotyping costs of the entire BMES population (Grant numbers 085475/B/08/Z and 085475/08/Z).