Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis

S Finfer; S McEvoy; R Bellomo; C McArthur; J Myburgh; R Norton; J French; G Doig; M Hayek; S O’Donnell; A Bell; N Boyce; D Blythe; J Cade; M Chapman; L Cole; DJ Cooper; A Davies; C French; C Joyce; S MacMahon; B Neal; J Presneill; P Saul; I Seppelt; D Stephens; A Turner; A Williams; C Woolfe; R Peto; P Sandercock; C Sprung; J Duncan Young; L Billot; M Fitzharris; Q Li; J Charlton; C Harry; L Higgins; K Moulden; S Vallance; J Chadderton; L Newby; S Bates; D Goldsmith; A Voss; A Palermo; L Francis; K Jayne; M Merai; S Pandey; M Schmidt; S Sivarajasingham; M Woodward; R Carroll; B McFadyen; J Clarke; J Powell; J Tai; I Hynesova; L Weisbrodt; L Bradley; T Kelly; A Limpus; R Moore; S Creed; S Kaplan; J Rivett; J Thomas; K Marsden; C Boyce; B Howe; M Robertson; A O’Connor; J Potter; N Ramakrishnan; C Powell; D Rajbhandari; K Girling; M Hodgetts; A Jovanovska; L Little

Journal article

Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis

S Finfer, S McEvoy, R Bellomo, C McArthur, J Myburgh, R Norton, J French, G Doig, M Hayek, S O’Donnell, A Bell, N Boyce, D Blythe, J Cade, M Chapman, L Cole, DJ Cooper, A Davies, C French, C Joyce Show all

Intensive Care Medicine | SPRINGER | Published : 2011

DOI: 10.1007/s00134-010-2039-6

Abstract

Purpose: To determine the effect of random assignment to fluid resuscitation with albumin or saline on organ function and mortality in patients with severe sepsis. Methods: Pre-defined subgroup analysis of a randomized controlled trial conducted in the intensive care units of 16 hospitals in Australia and New Zealand. Results: Of 1,218 patients with severe sepsis at baseline, 603 and 615 were assigned to receive albumin and saline, respectively. The two groups had similar baseline characteristics. During the first 7 days mean arterial pressure was similar in the two groups, but patients assigned albumin had a lower heart rate on days 1 and 3 (p = 0.002 and p = 0.03, respectively) and a highe..

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University of Melbourne Researchers

Jeffrey Presneill Author

Megan Robertson Author

Grants

Funding Acknowledgements

Funding bodies are listed alphabetically (Australia unless otherwise stated): Auckland District Health Board, New Zealand; Australian Commonwealth Department of Health and Aged Care; CSL Limited, Melbourne, Victoria; Middlemore Hospital, New Zealand; Australian National Health and Medical Research Council; Health Department of Western Australia; Health Research Council of New Zealand; New South Wales Health Department; Northern Territory Health Services; Queensland Health Services Department; Royal Hobart Hospital, Tasmania; South Australian Department of Human Services; Victorian Department of Human Services. The funding bodies played no part in the conduct or analysis of the study, or the decision to publish the results.