Journal article
Comparative analysis of the complete genome sequences of two Australian origin live attenuated vaccines of infectious laryngotracheitis virus
SW Lee, JM Devlin, JF Markham, AH Noormohammadi, GF Browning, NP Ficorilli, CA Hartley, PF Markham
Vaccine | ELSEVIER SCI LTD | Published : 2011
Abstract
Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that causes acute respiratory disease in poultry. Live attenuated ILTV vaccines have been used extensively to help control outbreaks of disease. Two Australian-origin attenuated vaccine strains, SA2 and A20 ILTV, are commercially available and are in frequent use in Australia. Both these vaccines are of chicken embryo origin (CEO). The A20 ILTV strain was developed from the SA2 ILTV strain by sequential passage of SA2 ILTV in tissue culture in order to reduce its residual virulence. Previous studies in our laboratories have demonstrated the greater attenuation of A20 ILTV under controlled experimental conditions, but the geneti..
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Funding Acknowledgements
The Rural Industries Research and Development Corporation, Australia, partly funded this study. JMD is supported by a fellowship from the Australian Research Council. NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy and the Australian Research Council through the ICT Centre of Excellence program. The authors thank Ivonne Petermann for her technical advice and assistance, and support of Kelly Ewen-White (both from Lifetechnologies, Mulgrave, Victoria).