Journal article

Consequences of suboptimal priming are apparent for low-avidity T-cell responses

Vanessa Venturi, Miles P Davenport, Natasha G Swan, Peter C Doherty, Katherine Kedzierska

IMMUNOLOGY AND CELL BIOLOGY | NATURE PUBLISHING GROUP | Published : 2012

Abstract

The emergence of the novel reassortant A(H1N1)-2009 influenza virus highlighted the threat to the global population posed by an influenza pandemic. Pre-existing CD8(+) T-cell immunity targeting conserved epitopes provides immune protection against newly emerging strains of influenza virus, when minimal antibody immunity exists. However, the occurrence of mutations within T-cell antigenic peptides that enable the virus to evade T-cell recognition constitutes a substantial issue for virus control and vaccine design. Recent evidence suggests that it might be feasible to elicit CD8(+) T-cell memory pools to common virus mutants by pre-emptive vaccination. However, there is a need for a greater u..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NIH


Awarded by ARC


Funding Acknowledgements

We thank Ken Field for FACS sorting and Dina Stockwell for technical assistance. This work was supported by Australian National Health and Medical Research Council (NHMRC) Project Grant (AI1008854) to KK, NHMRC Program Grant (AI567122) to PCD, NIH grant (AI170251) to PCD and ARC grant (DP1095581) to VV and MPD. KK is an NHMRC RD Wright Fellow, VV is ARC Future Fellow and MPD is an NHMRC Senior Research Fellow.