Inherited thrombophilias and adverse pregnancy outcomes: A case-control study in an Australian population

Abstract

Objective. The primary aim of this study was to examine the association between inherited thrombophilias and adverse pregnancy outcomes in an Australian population. Design. Case-control study. Setting. Two Australian tertiary level maternity hospitals. Population. One hundred and fifteen cases with adverse pregnancy outcomes, comprising severe pre-eclampsia (n=45), fetal growth restriction (n=44), placental abruption (n=16) or stillbirth (n=10), and 115 controls matched for ethnicity, parity and maternal age. Methods. Genotyping for factor V Leiden, prothrombin gene mutation, methylenetetrahydrofolate reductase 677 and 1298 and thrombomodulin polymorphism was performed using Taqman assays in..