Journal article

Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Neil J Glassford, KJ Farley, Stephen Warrillow, Rinaldo Bellomo

CRITICAL CARE AND RESUSCITATION | AUSTRALASIAN MED PUBL CO LTD | Published : 2011

Abstract

This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 µmol/L. After liver transplantation, ammonia uptake decreased to 0 µmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.