Journal article

The Outcome of Neutrophil Gelatinase-Associated Lipocalin-Positive Subclinical Acute Kidney Injury A Multicenter Pooled Analysis of Prospective Studies

Michael Haase, Prasad Devarajan, Anja Haase-Fielitz, Rinaldo Bellomo, Dinna N Cruz, Gebhard Wagener, Catherine D Krawczeski, Jay L Koyner, Patrick Murray, Michael Zappitelli, Stuart L Goldstein, Konstantinos Makris, Claudio Ronco, Johan Martensson, Claes-Roland Martling, Per Venge, Edward Siew, Lorraine B Ware, T Alp Ikizler, Peter R Mertens

Journal of the American College of Cardiology | ELSEVIER SCIENCE INC | Published : 2011

Abstract

OBJECTIVES: The aim of this study was to test the hypothesis that, without diagnostic changes in serum creatinine, increased neutrophil gelatinase-associated lipocalin (NGAL) levels identify patients with subclinical acute kidney injury (AKI) and therefore worse prognosis. BACKGROUND: Neutrophil gelatinase-associated lipocalin detects subclinical AKI hours to days before increases in serum creatinine indicate manifest loss of renal function. METHODS: We analyzed pooled data from 2,322 critically ill patients with predominantly cardiorenal syndrome from 10 prospective observational studies of NGAL. We used the terms NGAL(-) or NGAL(+) according to study-specific NGAL cutoff for optimal AKI pr..

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University of Melbourne Researchers