Journal article

Amniotic Fluid Eicosanoids in Preterm and Term Births: Effects of Risk Factors for Spontaneous Preterm Labor

Ramkumar Menon, Stephen J Fortunato, Ginger L Milne, Lina Brou, Claudine Carnevale, Stephanie C Sanchez, Leah Hubbard, Martha Lappas, Cayce Owens Drobek, Robert N Taylor

Obstetrics and Gynecology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011

Abstract

OBJECTIVE: To evaluate amniotic fluid arachidonic acid metabolites using enzymatic and nonenzymatic (lipid peroxidation) pathways in spontaneous preterm birth and term births, and to estimate whether prostanoid concentrations correlate with risk factors (race, cigarette smoking, and microbial invasion of amniotic cavity) associated with preterm birth. METHODS: In a case-control study, amniotic fluid was collected at the time of labor or during cesarean delivery. Amniotic fluid samples were subjected to gas chromatography, negative ion chemical ionization, and mass spectrometry for prostaglandin (PG) E2, PGF2α, and PGD2 and for 6-keto-PGF1α (thromboxane 2 and F2-isoprostane). Primary analysis..

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Grants

Awarded by National Institutes of Health, National Center for Research Resources


Awarded by University Research Committee


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Funding Acknowledgements

Supported in part by PHS grant UL1 RR025008 from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources, and University Research Committee award (2009163) to Ramkumar Menon.