Journal article

Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years

M Alvarez-Jimenez, JF Gleeson, LP Henry, SM Harrigan, MG Harris, E Killackey, S Bendall, GP Amminger, AR Yung, H Herrman, HJ Jackson, PD McGorry



BACKGROUND: In recent years there has been increasing interest in functional recovery in the early phase of schizophrenia. Concurrently, new remission criteria have been proposed and several studies have examined their clinical relevance for prediction of functional outcome in first-episode psychosis (FEP). However, the longitudinal interrelationship between full functional recovery (FFR) and symptom remission has not yet been investigated. This study sought to: (1) examine the relationships between FFR and symptom remission in FEP over 7.5 years; (2) test two different models of the interaction between both variables. METHOD: Altogether, 209 FEP patients treated at a specialized early psych..

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Awarded by Australian National Health and Medical Research Council

Awarded by Victorian Health Promotion Foundation

Funding Acknowledgements

This study was supported by a series of grants from the Australian National Health and Medical Research Council (grant number 350241) and the Victorian Health Promotion Foundation (grant number 91-0084C), together with generous funding from the Colonial Foundation to Orygen Youth Health Research Centre. The sponsors did not participate in the design or conduct of this study; in the collection, management, analysis, or interpretation of data; in the writing of the manuscript; or in the preparation, review, approval, or decision to submit this manuscript for publication. The authors particularly wish to thank all of the young people and family members who took part in the study, and the dedicated research team who conducted the interviews.